Bella, Ciao!
Today we're going to talk about mesotherapy. You might have not heard about it, maybe you have. However, in the fast-changing beauty world, it seems like topical treatment is not enough for the increasing demand of more targeted skin problem. That's where mesotherapy comes along and whispered to your ears "Bella, Ciao! How you doin'?"
What is mesotherapy for?
Mesotherapy involves tiny injections of medications or other substances into your skin or just beneath it. It's popular for treatment of wrinkle, melasma, skin brightening and fat loss.[1]
Advantages
Mesotherapy allows for targeted delivery of medications directly to the affected area, which reduces the systemic side effects.[2]
Compared to oral intake, mesotherapy avoids gastrointestinal breakdown and first-pass metabolism, leading to higher drug concentration at the site of action for enhanced efficacy.[2]
Mesotherapy offers the advantage of bypassing skin barriers and increasing drug absorption compared to topical application, ensuring deeper penetration and better therapeutic outcomes [2]
Potential side effects and adverse events
Side effects of mesotherapy were usually mild and transient [1]
During injection: patients can fell the burning, and itching sensations. Because of this, in most of the procedures, they use topical anesthesia under occlusion for nearly 45 min before mesotherapy to alleviate pain during injection.
Between few hours to few days: Patients can experience erythema, edema, swelling, irritation, bruising or ecchymosis. Application of ice-pack after mesotherapy for several hours can be used to mitigate erythema and swelling.
Occasionally, adverse effects such as acne formation, PIH (Post-inflammatory hyperpigmentation), stuffy feeling, and abscesses formation were reported.
References
Khalili M, Amiri R, Iranmanesh B, Zartab H, Aflatoonian M. Safety and efficacy of mesotherapy in the treatment of melasma: a review article. J Cosmet Dermatol. 2022; 21: 118–129. doi:10.1111/jocd.14644
Liao X, Cheng F, Jiang Y. Efficacy and safety of mesotherapy with tranexamic acid versus vitamin C in the treatment of melasma: A meta-analysis and systemic review. J Cosmet Dermatol. 2024; 00: 1-8. doi:10.1111/jocd.16353
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